| Eagle Airlines | ZN | EAV | 528 |
| Eagle Airways | EGT | ||
| Eagle Aviation | Y4 | EQA | 067 |
| Earth Airlines | ERX | ||
| EAS Airlines | EXW | ||
| East African Airlines | UGX | ||
| East African Safari Air | S9 | HSA | 895 |
| East Star Airlines | 8C | DXH | |
| East-West Airlines | EW | EWA | 804 |
| Eastern Airways | T3 | EZE | 467 |
| Eastern Australia Airlines | EAQ | ||
| Eastland Air | DK | ELA | |
| Easyjet | U2 | EZY | |
| Easyjet Switzerland | DS | EZS | |
| Ecopatrol | EKP | ||
| Ecuatoriana Airlines | EU | EEA | 341 |
| Edelweiss Air | EDW | ||
| EGA-Ecuato Guineana | EGA | ||
| Egyptair | MS | MSR | 077 |
| El Al Israel Airlines | LY | ELY | 114 |
| Elbe Air Lufttransport | LBR | ||
| Elbee Airlines | LBE | ||
| Eldorado - Lineas Aereas Eldorado | EDR | ||
| Elf Air Co | EFR | 934 | |
| ELIIP | EFE | ||
| ELK-Estonian Aviation Company | S8 | ELK | 520 |
| Emerald Airways | G3 | JEM | 938 |
| Emery Worldwide | EB | EWW | 591 |
| Emirates SkyCargo | EK | UAE | 176 |
| Empire Airlines | EM | CFS | 464 |
| Enimex | ENI | ||
| Enkor Airlines | ENK | ||
| Ensor Air | E9 | ENR | |
| Eos Airlines | E0 | ESS | |
| Era Aviation (Alaska Airlines Commuter) | 7H | ERH | 808 |
| Eritrean Airlines | B8 | ERT | |
| Estafeta Carga Aerea | E7 | ESF | 355 |
| Estonian Air | OV | ELL | 960 |
| Etelair Air Company | ETO | ||
| Ethiopian Airlines | ET | ETH | 071 |
| Etihad Airways Crystal Cargo | EY | ETD | 607 |
| Euralair International | RN | EUL | 836 |
| Euro Atlantic Airways | MM | MMZ | |
| Eurocypria Airlines | UI | ECA | 475 |
| Eurodirect Airlines | EUD | ||
| Eurofly | EEZ | ||
| EuroLine | MJX | ||
| Eurolot | K2 | ELO | |
| EuroManx | 3W | EMX | |
| European Air Cargo | EAC | ||
| European Air Express | EA | EAE | 024 |
| European Air Transport | QY | BCS | 615 |
| European Airlines | 2H | FRO | |
| European Airways | EAW | ||
| European Aviation | EAF | ||
| European Coastal Airlines | ECB | ||
| Eurosky Airlines | JO | ESK | 473 |
| Eurowings | EW | EWG | 104 |
| EVA Air | BR | EVA | 695 |
| Evergreen International Airlines | EZ | EIA | 494 |
| Everts Air Cargo | 3K | VTS | 029 |
| Excalibur Aviation | EXC | ||
| Excel Airways | JN | XLA | 812 |
| EXIN | EXN | ||
| Expo Aviation | 8D | EXV | 319 |
| Express | PSR | ||
| Express Air Services | FLN | ||
| Express Airways | |||
| Express One International | EO | LHN | |
| Express.Net Airlines | XNA |