| EAC | European Air Cargo | ||
| EAE | EA | 024 | European Air Express |
| EAF | European Aviation | ||
| EAQ | Eastern Australia Airlines | ||
| EAV | ZN | 528 | Eagle Airlines |
| EAW | European Airways | ||
| ECA | UI | 475 | Eurocypria Airlines |
| ECB | European Coastal Airlines | ||
| EDA | ED | Aerolineas Nacionales d. Ecuador (ANDES) | |
| EDR | Eldorado - Lineas Aereas Eldorado | ||
| EDW | Edelweiss Air | ||
| EEA | EU | 341 | Ecuatoriana Airlines |
| EEX | Avanti Air | ||
| EEZ | Eurofly | ||
| EFE | ELIIP | ||
| EFR | 934 | Elf Air Co | |
| EGA | EGA-Ecuato Guineana | ||
| EGF | American Eagle | ||
| EGT | Eagle Airways | ||
| EIA | EZ | 494 | Evergreen International Airlines |
| EIN | EI | 053 | Aer Lingus Cargo |
| EKP | Ecopatrol | ||
| ELA | DK | Eastland Air | |
| ELG | E8 | 789 | ALPI Eagles |
| ELK | S8 | 520 | ELK-Estonian Aviation Company |
| ELL | OV | 960 | Estonian Air |
| ELO | K2 | Eurolot | |
| ELY | LY | 114 | El Al Israel Airlines |
| EMX | 3W | EuroManx | |
| ENI | Enimex | ||
| ENK | Enkor Airlines | ||
| ENR | E9 | Ensor Air | |
| EPA | J5 | Shenzhen Donghai Airlines | |
| EPC | DD | Conti-Flug | |
| EQA | Y4 | 067 | Eagle Aviation |
| EQL | KY | 980 | Air Sao Tome e Principe |
| ERG | Aviaenergo | ||
| ERH | 7H | 808 | Era Aviation (Alaska Airlines Commuter) |
| ERT | B8 | Eritrean Airlines | |
| ERV | 998 | Yerevan Avia | |
| ERX | Earth Airlines | ||
| ESA | Seagreen Air Transport | ||
| ESF | E7 | 355 | Estafeta Carga Aerea |
| ESK | JO | 473 | Eurosky Airlines |
| ESL | P7 | 215 | Russian Sky Airlines |
| ESS | E0 | Eos Airlines | |
| ETC | ML | Trans Attico | |
| ETD | EY | 607 | Etihad Airways Crystal Cargo |
| ETH | ET | 071 | Ethiopian Airlines |
| ETO | Etelair Air Company | ||
| EUD | Eurodirect Airlines | ||
| EUL | RN | 836 | Euralair International |
| EVA | BR | 695 | EVA Air |
| EWA | EW | 804 | East-West Airlines |
| EWG | EW | 104 | Eurowings |
| EWW | EB | 591 | Emery Worldwide |
| EXC | Excalibur Aviation | ||
| EXN | EXIN | ||
| EXS | LS | Jet2.com | |
| EXV | 8D | 319 | Expo Aviation |
| EXW | EAS Airlines | ||
| EXY | XZ | 83 | South African Express Airways |
| EYT | EY | Societe Nouvelle Europe Aero Service | |
| EZE | T3 | 467 | Eastern Airways |
| EZS | DS | Easyjet Switzerland | |
| EZT | Zenit Air Company | ||
| EZX | Z7 | 247 | Zimbabwe Express Airlines |
| EZY | U2 | Easyjet |